Lithium Delays the Radiation-induced Apoptotic Process in External Granule Cells of Mouse Cerebellum.

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Lithium delays the radiation-induced apoptotic process in external granule cells of mouse cerebellum.

Proliferating cells of the external granular layer (EGL) in the developing cerebellum are highly sensitive to ionizing radiation. We examined the effect of lithium, an inhibitor of intracellular signaling, on the manifestation of radiation-induced apoptosis. Newborn mice were exposed to 0.5 Gy gamma-irradiation alone, or first were treated with lithium (10 mumol/g, SC) then given 0.5 Gy irradia...

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ژورنال

عنوان ژورنال: Journal of Radiation Research

سال: 1995

ISSN: 0449-3060,1349-9157

DOI: 10.1269/jrr.36.203